Developments in anaplastic large-cell lymphoma: targeting the anaplastic lymphoma kinase

Primary gastric anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma

INTRODUCTION Most primary stomach lymphomas are now recognized to originate from B-cell. Primary gastric anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) as shown in this case is very rare. CASE REPORT A 59-year-old man presented with a 1-month history of epigastric pain. Computed tomography showed a tumor in the stomach with perigastric lymphadenopathy. Biopsy ...

ALK- negative Anaplastic Large Cell Lymphoma of Bone

Anaplastic Large Cell Lymphoma Associated With Breast Implants

A forty two years old woman with a history of bilateral breast augmentation for cosmetic reasons was presented for poor healing of the surgical site. Tissue and periprosthetic fluid were removed from the wound site revealing an atypical lymphoid infiltrate. Subsequently the patient developed axillary lymph adenopathy. Excisional biopsy was performed. Flow cytometry was non-diagnostic. She conti...

Expression of Anaplastic Lymphoma Kinase Protein in Human Breast Cancer

Background & Objectives: Anaplastic lymphoma Kinase (ALK) is a receptor tyrosine kinase involved in the genesis of several human cancers. ALK was initially identified because of its involvement in anaplastic large cell lymphoma (ALCL). ALK is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. Studies reveal that the presence of anti-ALK antibodies ...

Ceritinib in patients with advanced anaplastic lymphoma kinase-rearranged anaplastic large-cell lymphoma.

The anaplastic lymphoma kinase (ALK) gene is expressed in.50% of anaplastic large-cell lymphomas (ALCLs). Although most patients withALK-positiveALCL respondwell to anthracycline-based chemotherapy, relapses do occur (5-year failure-free survival 60%) and require salvage therapy, generally with poor outcomes. Autologous stem cell transplant is an option in the salvage setting, but not all patie...